We are seeking a motivated junior postdoctoral candidate to join a Sinergia project on the study of toxin-antitoxin systems in bacteria using NGS sequencing.
Toxin-antitoxin systems (TAS) have emerged as key determinants of bacterial persistence/dormancy, antibiotic tolerance and virulence. Many of these TAS are specific RNases that are found at a surprising diversity in bacterial genomes. We will use various NGS methods (Mut-Seq, Shotgun-Seq, Tn-Seq) to identify new TAS, e.g., RNases toxins and their specific mRNA targets, or other potential TAS.
Of course these methods require new bioinformatics algorithms and the development of biologist friendly analysis pipelines.
The position is funded for three years.
Our lab, the Bioinformatics Core Facility of Fribourg, is located at the Biology department of the University of Fribourg on the Pérolles campus. We offer a stimulating working environment, cutting-edge computational infrastructures by access to HPC clusters in Lausanne (Vital-IT) and Bern (Interfaculty Bioinformatics Unit). The candidate will be affiliated to the SIB Swiss Institute of Bioinformatics.